. 2021 Sep 16;125(11):1593–1597. doi: 10.1038/s41416-021-01541-4

Table 2.

Number of participants with features of possible cancer in selected risk bands (and comparison to PPV ≥ 3%), in 150,921 English patients aged ≥40 years.

	PPV ≥ 3%							PPV ≥ 2%					PPV ≥ 1%
	Number qualifying	Additional number qualifying for PC testing	Estimated number positive tests	Adjusted number qualifying for referral after PC testing	Adjusted number/100,000 population after PC testing [95% CI]	Number qualifying	Additional number qualifying for PC testing	Estimated number positive tests	Adjusted number qualifying for referral after PC testing	% change from PPV ≥ 3%	Adjusted number/100,000 population after PC testing [95% CI]	Number qualifying	% change from PPV ≥ 3%	Number/100,000 population [95% CI]
Colorectal	5125	1776	282	5407	3583 [3489, 3678]	5440	1461	232	5672	5	3758 [3663, 3855]	6901	28	4573 [4468, 4679]
Prostate	894			894	592 [554, 632]	1046			1046	17	693 [652, 736]	1126	26	746 [703, 791]
Lung	803	2503	30	833	552 [515, 591]	963	2343	28	991	19	657 [617, 699]	3306	297	2191 [2117, 2266]
Breast	293			293	194 [173, 218]	311			311	6	206 [183, 231]	474	62	314 [286, 344]
Kidney	263			263	174 [154, 197]	263			263	0	174 [154, 197]	961	265	637 [597, 678]
Bladder	246			246	163 [143, 184]	246			246	0	163 [143, 185]	841	242	557 [520, 596]
Upper GI	211			211	140 [122, 160]	249			249	18	165 [145, 187]	5044	2291	3342 [3252, 3434]
Ovary	128	31	2	130	86 [72, 102]	149	10	1	150	15	99 [84, 117]	159	22	105 [90, 123]
Endometrium	109			109	72 [59, 87]	124			124	14	82 [68, 98]	244	124	162 [142, 183]
Larynx	111			111	74 [61, 89]	142			142	28	94 [79, 111]	142	28	94 [79, 111]
Pancreas	78			78	52 [41, 65]	97			97	24	64 [52, 78]	319	309	211 [189, 236]
Totals	8261^a			8576	5682 [5566, 5800]	9030^b			9291	8	6156 [6035, 6279]	19517^c	136	12932 [12763, 13102]

The risk bands are cumulative. Thus a participant in the ≥3% risk band also appears in the ≥2% risk band and the ≥1% risk band.

Upper GI upper gastrointestinal (oesophagus or stomach), PC primary care.

^aTotal of 8261 in 6898 unique participants.

^bTotal of 9030 in 7453 unique participants.

^cTotal of 19,517 in 10,649 unique participants.