Figure 5.

Three RNA features define the condensation-binding relationships

(A) Binding regions were defined based on motifs proximal to crosslinks, and each region was allocated to one of 36 classes defined by the region length, motif density, and dominant motif type. The count of cDNAs falling into each class of binding regions from each iCLIP dataset was determined and normalized by the average cDNA count across all datasets within this experiment. Duplicate samples were obtained for each TDP-43 variant. Blue color represents depletion compared with the average, and gray represents enrichment. This is linked to Table S2 containing quantification of cDNA counts from CLIP samples overlapping with the binding regions together with their genomic coordinates, region, gene ID and gene names, and derived classifications in groups by length, density, and base content.