Table 3.

Association of overall survival with the pretreatment EBV DNA level (n=16).

Study (Author/Year of publication)	Study design(P/R) a	Sample size	Cutoff value b	HR (high vs. low)	95% CI	P value	Survival probabilities	P value	Quality score
Chen M, Yin L, Wu J (2015) (53)	P	165	Positive vs negative	–	–	–	2-year OS: Negative EBV 100% vs. positive EBV 94%	1.000	5
Tang (2015) (54)	P/R	6337	4000	8.44	(6.15–11.57)	<0.001	–	–	4
Yang (2015) (55)	R	1168	3760	1.41	(1.06–1.88)	0.017	–	–	4
Zhao (2015) (56)	R	637	1500	1.83	(0.79–4.24)	0.161	–	–	4
Chen (2016) (57)	R	404	4000	3.75	(1.701–8.284)	<0.001	3-year OS: 85% vs. 98%	<0.001	4
Lv (2016) (59)	R	1501	4000	1.97	(1.42 – 2.75)	<0.001	5-year OS: 81% vs. 91%	<0.001	6
Peng H, Chen L, Zhang Y (2016) (117)	R	1106	Positive vs negative	1.83	(1.08–3.11)	0.026	4-year OS: 86% vs. 94%	<0.001	3
Peng H, Guo R, Chen L (2016) (60)	R	584	2010	4.581	(1.58–13.26)	0.005	3-year OS: 92.3% vs. 98.9%	<0.001	3
Zhang (2016) (57)	R	1467	4000	3.44	(2.32–5.09)	<0.001	5-year OS: 83% vs. 95%	<0.001	6
Jin YN, Yao JJ, Zhang F (2017) (61)	R	1036	1500	1.65	(1.10–2.47)	N/A	5-year OS: 79% vs. 87%	0.002	6
Du (2019) (66)	R	607	4000	2.16	(1.25–3.71)	0.005	5-year OS: 85% vs. 97%	<0.001	4
Guo (2019) (67)	R	979	N/A	1.29	(1.13–1.48)	0.001	–	–	4
Huang CL, Sun ZQ, Guo R (2019) (68)	R	949	7000	1.86	(0.77–4.53)	0.171	3-year OS: 95% vs. 89%	0.138	5
Sun XS, Chen WH, Liu SL (2019) (70)	R	2742	1460	3.58	(2.50–5.13)	<0.001	–	–	4
Sun XS, Liang YJ, Liu SL (2019) (69)	R	226	25000	1.91	(1.23–2.96)	0.004	–	–	3
Sun XS, Liu LT, Liu SL (2019) (69)	R	502	Detectable vs undetectable	–	–	–	3-year OS: 34% vs. 69%	<0.001	4

(deleted)^aStudy design: prospective (P)/retrospective (R). ^b Cutoff values: pretreatment EBV DNA level (copies/mL).

HR, hazard ratio; CI, confidence interval; OS, overall survival.

N/A, Not available.