Table 4.
Association of overall survival with tumor volume (n=11).
| Study (Author/Year of publication) | Study design(P/R)a | Sample size | Primary (P) or nodal (N) cutoff volume (cm3) | HR(high vs. low) | 95% CI | P value | Survival probabilities b | P value | Quality score |
|---|---|---|---|---|---|---|---|---|---|
| Tian (2015) (72) | R | 229 | 38 (P) | – | – | – | 5-year OS: 15.2% vs. 48.7% | <0.01 | 4 |
| He (2016) (73) | R | 358 | 46.4 (P) | 2.46 | 1.48–4.10 | 0.001 | 3-year OS: 75.5% vs. 90.5% | <0.001 | 5 |
| Lu (2016) (74) | P | 180 | 20 (P) | – | – | – | 5-year OS: 70.6% vs. 95.1% | 0.001 | 4 |
| Qin (2016) (76) | P | 249 | 33 (P) | 1.01 (per cm3) | 1.003–1.018 | 0.04 | 5-year OS: 70.5% vs. 86.1% | 0.006 | 3 |
| Luo Y, Gao Y, Yang G (2016) (75) | R | 110 | 14.1 (N) | 1.875 | 1.001–3.512 | 0.050 | 5-year OS: 53.0% vs. 75.6% | 0.028 | 4 |
| Chen (2017) (77) | R | 1230 | 7.2/35.7 (N) | 1.72 (7.2–35.7 vs. ≤7.2) / 3.41(>35.7 vs. ≤7.2) | 1.09–2.69 1.93–6.04 |
0.019 <0.001 |
5-year OS: ≤7.2: 90.2% vs. 7.2–35.7: 88.2% vs. >35.7: 62.3% |
<0.001 | 6 |
| Liang (2017) (79) | R | 455 | 28 (P) | 3.231 | 1.776–5.878 | <0.001 | 4-year OS: 75.4% vs. 95.1% | <0.001 | 4 |
| Liu T, Lv J, Qin Y (2017) (81) | P | 143 | 43.5 (P) 15.0 (N) |
7.81 3.55 |
1.79–33.3 1.33–9.43 |
0.006 0.011 |
5-year OS: 68% vs. 97% 5-year OS: 74% vs. 91% |
<0.001 <0.001 |
5 |
| Zhang (2017) (78) | R | 393 | 23 (P) | 2.05 | 1.11–3.80 | 0.022 | – | – | 3 |
| Chen (2018) (63) | P | 385 | 30 (P) | – | – | – | 3-year PFS: 89% vs. 96% | 0.008 | 4 |
| Jeong (2018) (80) | R | 133 | 33 (P) | 2.93 | 1.16–7.42 | 0.013 | 5-year OS: 67% vs. 87% | 0.021 | 5 |
aStudy design: prospective (P)/retrospective (R). bSurvival outcomes: OS, overall survival; PFS, progression-free survival. HR, hazard ratio; CI, confidence interval