Table 6.
Association of overall survival with PET parameters (n=10).
| Study(Author/Year of publication) | Study design(P/R)a | Sample size | Nature of PET parameters | Cutoff value | HR (high vs. low) | 95% CI | P value | Survival probabilities(overall survival) | P value | Quality score |
|---|---|---|---|---|---|---|---|---|---|---|
| Yoon (2014) (99) | R | 53 | SUVmax-T MTV-T2.5 MTV-T3.0 |
≥8.9 ≥31.45 cm3 ≥23.01 cm3 |
1.08 5.03 5.03 |
0.25–7.71 1.04–24.24 1.04–24.24 |
0.74 0.029 0.029 |
– | – | 3 |
| Zaghloul (2014) (100) | R | 70 | SUVmax-T | ≥8.0 | – | – | 0.034 (U) | – | – | 3 |
| Hsieh (2015) (101) | R | 174 | SUVmax-T | ≥8.35 | 3.91 | 1.45–10.53 | 0.007 | 5-year OS: 69.2% vs. 93.4% | 0.001 | 4 |
| Shen T, Tang LQ, Luo DH (2015) (102) | R | 194 (107: LR; 87: DM) | SUVmax-T or SUVmax-M | ≥8.65 (LR) ≥13.55 (DM) |
4.882 2.415 |
1.06–22.59 0.96–6.10 |
0.042 0.062 |
– | – | 4 |
| Xiao W, Xu A, Han F (2015) (103) | R | 179 | SUVmax-T | ≥10.22 | – | – | – | 5-year OS: 66.6% vs. 87.6% | <0.001 | 5 |
| Yoon (2016) (104) | R | 97 | TLG | 322.7 | 0.29 | 0.11–0.79 | 0.02 | 5-year OS: 54.0% vs. 85.7% | 0.003 | 6 |
| Lee (2017) (108) | R | 53 | SUVmax-T SUVmax-N |
≥13.2 ≥13.4 |
- 7.799 |
- 1.51–40.40 |
- 0.014 |
- 3-year OS: 33.1% vs. 55.5% |
- 0.003 |
5 |
| Liu F, Xi XP, Wang H (2017) (109) | R | 213 | PET-CT-guided dose-painting IMRT vs CT-based IMRT | – | 0.425 | 0.18–1.009 | 0.052 | 3-year OS: 82.6% vs. 91.8% | 0.049 | 5 |
| Alessi (2019) (111) | R | 160 | SUVmax-T SUVmean-T TLG |
18.8 9.5 382.2 |
1.07 1.07 1.003 |
- - - |
0.01 0.01 0.01 |
– | – | 3 |
| Sun XS, Liang YJ, Liu SL (2019) (113) | R | 253 | SUVmax-T, SUVmax-N SUVmax-M |
17.0 12.7 6.9 |
- 1.40 1.72 |
- 0.95–2.06 1.13–2.78 |
- 0.087 0.012 |
3-year OS: SUVmax-T: >17 vs. ≤17: 47.7% vs. 57.3% 3-year OS: SUVmax-N: >12.7 vs. ≤12.7: 46.5% vs. 65.1% 3-year OS: SUVmax-M: >6.9 vs. ≤6.9: 49.2% vs. 65.4% |
SUVmax-T: 0.48 SUVmax-N: 0.005 SUVmax-M: 0.005 |
5 |
aStudy design: prospective (P)/retrospective (R).
HR, hazard ratio; CI, confidence interval; SUVmax, maximum standardized uptake value; SUVmean, mean standardized uptake value; MTV, metabolic tumor volume; TLG, total lesion glycolysis; T, primary tumor; N, lymph node; M, metastasis; LR, local recurrence.