Figure 11.

CP-93129 acts via 5-HT1B receptors located on presynaptic SPN terminals. A, Example recording of IPSC amplitudes in a D2-SPN (D1-Cre mouse) with serotonin receptor antagonist SB-216641 and agonist CP-93129. Recording started in the presence of SB-216641 and CP-93129 was added to the bath after 15 min. B, Average IPSC amplitude change in D2-SPNs (D1-Cre mice) during drug treatment (N = 5). Horizontal line at 100% was added as visual guideline. Each point is an average of six IPSC events. Dotted lines represent SEM IPSC amplitude change was normalized against minutes 10–15 (baseline). The traces on the right are examples recorded during baseline (black), drug treatment (light gray), and washout (dark gray). The black bar represents the 2-ms light pulse. C, Average group synaptic success rate of D2-SPNs (D1-Cre mice) with SB-216641 and CP-93129. Dotted lines represent SEM. D, Before and after plot of average IPSC amplitude change of D2-SPNs (D1-Cre mice) during drug treatment. Bars represent the mean. All recordings were done in the presence of KA. ns, p > 0.05; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.