Figure 4.

Drug application does not affect ChR2-evoked APs. A, Example AP triggered in a D2-SPNs (D1-Cre mouse) by a 2-ms light pulse before (left), during (middle), and after drug treatment (black traces). Each trace is an average of 180 individual traces. Control APs (gray traces) did not receive CP-93129. B, Effect of repeated AP triggering over time. Triangles, half width; square, occurrence of AP. N = 3: D1-Cre (2), A2a-Cre (1). Values are MEAN ± SEM. C, Effect of bath-applied CP-93129. N = 3: D1-Cre (3).