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. 2021 Sep 15;41(37):7831–7847. doi: 10.1523/JNEUROSCI.1037-20.2021

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Copyright © 2021 Pommer et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 8. — CP-93129 affects ChR2-evoked IPSCs in D1-SPNs up to 30 ms after optical stimulation. A, Average distribution and amplitude of IPSCs recorded in D1-SPNs (A2a-Cre mice) within the first 10 ms after the light stimulus. Note the higher average amplitude compared with D2-SPNs. The yellow area indicates application of CP-93129. Each episode equals 5 s. B, Average IPSC amplitude of all recorded IPSCs in D1-SPNs (A2a-Cre mice) with a latency of ≤10 ms over 60 min. The two dotted lines mark the application of CP-93129. C, Statistical analysis of average IPSC amplitude within 10 ms after the light pulse in D1-SPNs (A2a-Cre mice) during baseline, drug treatment, and washout. IPSC recovery did not reach baseline levels. Values are mean ± SD. D, Average distribution and amplitude of IPSCs recorded in D1-SPNs (A2a-Cre mice) between 10 and 30 ms after the light stimulus. The yellow area indicates application of CP-93129. Each episode equals 5 s. E, Average IPSC amplitude of all recorded IPSCs in D1-SPNs (A2a-Cre mice) with a latency between 10 and 30 ms over 60 min. The two dotted lines mark the application of CP-93129. F, Statistical analysis of average IPSC amplitude between 10 and 30 ms after the light pulse in D1-SPNs (A2a-Cre mice) during baseline, drug treatment, and washout. Values are mean ± SD. G, Average distribution and amplitude of IPSCs recorded in D1-SPNs (A2a-Cre mice) between 30 and 100 ms after the light stimulus. Each episode equals 5 s. H, Average IPSC amplitude of all recorded IPSCs in D1-SPNs (A2a-Cre mice) with a latency between 30 and 100 ms over 60 min. I, Statistical analysis of average IPSC amplitude between 30 and 100 ms after the light pulse in D1-SPNs (A2a-Cre mice) during baseline, drug treatment, and washout. Values are mean ± SD; N = 6. ns, p > 0.05; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.