Loss of APOE results in reduced tumor burden and fibrosis. A, Experimental scheme for orthotopic transplantation of 7940b, KPC tumor cells. B, Final tumor weight (g) in WT (n = 10) and ApoE–/− (n = 13) mice. Statistical significance was determined using two-tailed t test, with a P < 0.05 considered statistically significant. C, Representative IHC for APOE in WT and ApoE–/− mice. Scale bar, 100 μm. D, Representative IHC staining for Ki-67, cleaved caspase-3 (CC3), F4/80, and CD3 in WT and ApoE–/− mice. Scale bars, 100 μm. E, Quantitation of IHC stain as a percentage area per 20× field in WT (n = 4–8) and ApoE–/− mice (n = 5–8). Statistical significance was determined by two-tailed t tests. n.s., not significant.