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. 2021 Sep 2;12:666449. doi: 10.3389/fphys.2021.666449

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Copyright © 2021 Cai, Wen, Ma, Mai, Zhan, Wang, Zhang, Chen, Li, Wu, Li and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of Huang-Lian-Jie-Du decoction (HLJDD) on plaques stability of carotid lesion in ApoE^−/− mice with atherosclerosis (AS). (A) Representative MASSON, immunohistochemical staining of α-SMA and MOMA-2 in carotid arteries sections are shown. Magnification, ×200; scale bar=200μm. (B) The positive radio of collagen content in carotid sections by masson trichrome staining. Values are expressed as the mean±SD. (C) The average optical density of α-SMA in carotid sections was semi quantitatively analyzed by Image Pro Plus 6.0 software. Values are expressed as the mean±SD. (D) The average optical density (OD) of MOMA-2 in carotid sections was semi quantitatively analyzed by Image Pro Plus 6.0 software. Values are expressed as the mean±SD (n=5; ^#p<0.05 and ^##p<0.01 vs. the control group; ^*p<0.05 and ^**p<0.01 vs. the model group; one-way ANOVA).