FIG 4.

Reduced bone volumes are associated with the local bacterial burden with HOM induced by clinical isolates. (A) Trabecular BV/TV ratio measured by microCT of femurs from noninjected control mice (same cohort as in Fig. 2) and mice injected with either TI1, TI2, or TI3. Classification as BLI⁻ or BLI⁺ legs was determined by the threshold in the Fig. 3 legend. *, P ≤ 0.0014 for the control versus all other groups as calculated by one-way ANOVA with Tukey’s multiple-comparison post hoc test. P values between BLI⁻ and BLI⁺ BV/TV ratios within each strain were calculated by Student’s t test. (B) Correlation of the BV/TV data from panel A with the BLI signal from the corresponding leg. Dot coding corresponds to the coding in panel A.