FIG 7.

Effects of S. aureus strains on bone cells in vitro. (A) Intracellular proliferation within cultured osteoclasts measured by the change in CFU between 1.5 and 18 h postinfection. *, P ≤ 0.0015 compared to all other strains as measured by one-way ANOVA with Tukey’s post hoc test. (B) MC3T3 survival after 22 h of exposure to medium with either 5% or 10% concentrated S. aureus culture supernatant, relative to a medium-only control. Bars represent the means, and error bars are SD (n = 10). # and @, P < 0.0001 compared to all other 5% supernatants; *, P < 0.0001 compared to all other 10% supernatants (by two-way ANOVA with Tukey’s post hoc test).