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. 2021 Sep 16;89(10):e00307-21. doi: 10.1128/IAI.00307-21

FIG 4.

FIG 4

B. burgdorferi is inhibited by RoF. (A) B. burgdorferi was cultured in BSK-II medium alone or in medium supplemented with DMSO (RoF vehicle) or the indicated concentrations of RoF (0 to 200 μM). (B) B31 and 2D7 were grown in BSK-II medium supplemented with DMSO or 100 μM RoF. (C) B31 was cultured in BSK-II medium supplemented with DMSO or various concentrations of RF (0 to 200 μM). (D) B31 was cultured in BSK-II medium alone or in medium supplemented with an inhibitory concentration RoF (100 μM) and/or RF (50 or 100 μM). All cultures were grown for 8 days at 37°C. The concentration of DMSO added to medium reflected the amount of DMSO added for each respective RoF concentration. Bars represent the means from three independent experiments. Error bars indicate SD. Two-way ANOVA and Tukey’s post hoc test were used for multiple comparisons. ns, not significant; **, P < 0.01; ****, P < 0.0001.