TABLE 1.

CAUTI disease severity^a

CAUTI disease severity	24-h standard CAUTI model			96-h standard CAUTI model			24-h precolonized CAUTI model			24-h standard CAUTI model vs 24-h precolonized CAUTI model (WT comparison)
	WT	ΔkatA mutant	P value	WT	ΔkatA mutant	P value	WT	ΔkatA mutant	P value	CAUTI	Precolonized	P value
Bladder hematoma and/or blood in urine	0/12	0/12	N/A	0/14	0/13	N/A	8/11	0/11	0.0004	0/12	8/11	0.0003
Kidney hematoma	0/12	0/12	N/A	0/14	0/13	N/A	2/11	0/11	0.1380	0/12	2/11	0.1221
Kidney color change and/or mottling	0/12	0/12	N/A	3/14	3/13	N/A	8/11	5/11	0.1930	0/12	8/11	0.0003
Kidney stone	0/12	0/12	N/A	5/14	2/13	0.2280	4/11	0/11	0.0270	0/12	4/11	0.0215
Any abnormality	0/12	0/12	N/A	7/14	4/13	0.3090	9/11	5/11	0.0760	0/12	9/11	0.0001

^aAll mice were assessed for the following parameters at the time of urine collection and euthanasia: bladder hematoma and/or blood in urine, kidney hematoma, kidney color change and/or mottling, and kidney stones. “Any abnormality” indicates whether at least one of these parameters was detected in a mouse. Data represent the number of mice positive for the above parameters out of the total number of mice infected for each strain during 24 h and 96 h of the standard CAUTI model and during 24 h of the precolonized CAUTI model, as well as a comparison of mice infected with the WT between the two models at 24 h. P values were determined by the chi-square test. N/A, not applicable.