Table 1.
Demographic and clinical characteristics at baseline of nfvPPA, lvPPA and healthy controls
| nfvPPA | lvPPA | HC | F | P | |
|---|---|---|---|---|---|
| n = 39 | n = 40 | n = 40 | |||
| Sex (M:F) | 17:22 | 15:25 | 20:20 | 1.27# | 0.53 |
| Age (years) | 65.5 ± 9.5 | 66.9 ± 7.4 | 64.9 ± 6.6 | 0.66 | 0.51 |
| Education (years)a | 13.0 ± 3.2 | 12.2 ± 3.3 | 13.3 ± 3.0 | 1.39 | 0.25 |
| Handedness (L:R) | 3:36 | 3:37 | 0:40 | 3.20# | 0.20 |
| English as first languageb | 28 | 39 | 39 | 17.55# | <0.001 |
| Disease duration (years) | 3.3 ± 2.2 | 3.5 ± 2.5 | – | 0.20 | 0.65 |
| FRS (Rasch score)c | 2.3 ± 1.8 | 1.5 ± 1.8 | – | 3.71 | 0.06 |
| Number of assessmentsd | 2 [1–6] | 2 [1–4] | – | 0.51^ | 0.52 |
| Baseline | 39 | 40 | 40 | – | – |
| Year 2 | 25 | 22 | – | – | – |
| Year 3 | 11 | 12 | – | – | – |
| Year 4 | 3 | 2 | – | – | – |
| Year 5 | 1 | 0 | – | – | – |
| Year 6 | 1 | 0 | – | – | – |
| Total | 80 | 76 | 40 | – | – |
Values are mean ± standard deviation, with the exception of dwhere values are expressed as median [range]. #Chi-square value. ^t-statistic value. FRS, Frontotemporal dementia Rating Scale; HC, healthy controls; lvPPA, logopenic variant primary progressive aphasia; nfvPPA, non-fluent variant primary progressive aphasia. Missing data: aYears of education missing for 1 control; bFirst language in non-native English speakers; nfvPPA (n = 11): Slavic (3; Hungarian, Latvian/Russian, Croatian); Romance (2, Italian); Semitic (2; Arabic, Maltese); Germanic (2, German, Dutch); African (1; Afrikaans); Dravidian (1, Mayalayam); lvPPA (n = 1) = Germanic (1; Dutch). English as first language missing for 1 control; cFRS score missing for 3 nfvPPA and 2 lvPPA; dNumber of MRI and clinical assessments.