Table 1. Association and evaluation of cancer PRS across ancestry groups.
| GWAS Trait/Outcome | PRS Method (SNPs) | Ancestry Group | n Cases | n Controls | PRS Association | PRS Evaluation AAUC (95% CI) |
|
|---|---|---|---|---|---|---|---|
| Odds Ratio* (95% CI) | P | ||||||
| Overall Breast Cancer | GPRS (334) | EUR | 14109 | 214163 | 1.594 (1.567, 1.622) | 1.7x10-613 | 0.628 (0.623, 0.632) |
| SAS | 149 | 3598 | 1.451 (1.231, 1.71) | 8.80x10-6 | 0.603 (0.557, 0.651) | ||
| AFR | 116 | 3666 | 1.442 (1.199, 1.735) | 0.00011 | 0.6 (0.546, 0.65) | ||
| EAS | 45 | 1069 | 1.852 (1.385, 2.475) | 3.20x10-5 | 0.676 (0.59, 0.757) | ||
| CSPRS (1,120,410) | EUR | 14109 | 214163 | 1.771 (1.739, 1.803) | 5.4x10-857 | 0.653 (0.648, 0.657) | |
| SAS | 149 | 3598 | 1.656 (1.4, 1.958) | 4.00x10-9 | 0.641 (0.594, 0.687) | ||
| AFR | 116 | 3666 | 1.761 (1.453, 2.134) | 7.90x10-9 | 0.651 (0.598, 0.701) | ||
| EAS | 45 | 1069 | 1.761 (1.297, 2.39) | 0.00029 | 0.66 (0.585, 0.735) | ||
| Prostate Cancer | GPRS (377) | EUR | 6561 | 182590 | 1.943 (1.894, 1.993) | 3.1x10-566 | 0.68 (0.674, 0.687) |
| SAS | 51 | 4305 | 1.785 (1.389, 2.295) | 6.00x10-6 | 0.652 (0.576, 0.726) | ||
| AFR | 144 | 2681 | 1.501 (1.254, 1.796) | 9.70x10-6 | 0.615 (0.567, 0.66) | ||
| EAS | 7 | 622 | 1.63 (0.83, 3.205) | 0.16 | 0.619 (0.442, 0.811) | ||
| CSPRS (1,120,596) | EUR | 6561 | 182590 | 2.14 (2.085, 2.197) | 4.2x10-711 | 0.702 (0.695, 0.708) | |
| SAS | 51 | 4305 | 2.383 (1.826, 3.111) | 1.70x10-10 | 0.745 (0.684, 0.8) | ||
| AFR | 144 | 2681 | 1.325 (1.107, 1.586) | 0.0021 | 0.579 (0.527, 0.63) | ||
| EAS | 7 | 622 | 1.943 (1.005, 3.755) | 0.048 | 0.626 (0.385, 0.853) | ||
Analyses were adjusted for birth year, genotyping array, and first ten principal components. Odds ratios are given per standard deviation within ethnic group. Abbreviations: AAUC, covariate-adjusted area under the receiver-operator characteristics curve; CI, confidence interval; GWAS, genome-wide association study; PRS, polygenic risk score; GPRS: GWAS Hits-based PRS; CSPRS: PRS-CS based PRS; SNP, single nucleotide polymorphism; AFR: African; EAS: East Asian; EUR: European, SAS: South Asian