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(A) synergistic effects of D-11 with multiple antibiotics. The FICI values of D-11 combined with multiple antibiotics and the fold change of MICs of those antibiotics in the presence of 4 μM D-11. (B) The heat map of the FIC indices for the synergistic effects of multiple antimicrobial agents combined with 4 μM D-11 against three standard P. aeruginosa strain and nine clinical isolates. Synergy is indicated by an FIC index ≤ 0.5.
