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. 2021 Sep 3;15(9):e0009743. doi: 10.1371/journal.pntd.0009743

Fig 1. V. cholerae specific plasma antibody titers rise rapidly following vaccination and are maintained at least for one year post vaccination.

Fig 1

(A) Vibriocidal and (B) Agglutination titers on day 0, 7, 10, 15, 30, 90, and 365 for each of the 12 subjects following vaccination. Dotted line in the vibriocidal and agglutination figures indicate the lowest dilution of serum tested in the assay. (C) Longitudinal vibriocidal titers measured for each of the 12 subjects following vaccination from day 0 to day 365. Half-life (T½) estimated by an exponential decay model using the average vibriocidal titers for all subjects (Line bolded in red). Half-life estimate has been calculated from day 30–90 (first set of dashed lines), and from day 90–365 (second set of dashed lines). Dotted line indicates the lowest dilution of serum used in the assay. (C) Anti lipopolysaccharide and (D) anti cholera toxin B subunit titers for IgM, IgG, and IgA plasma antibodies on days 0, 7, 10, 15, 30, 90, and 365 for each of the 12 subjects following vaccination. Statistical significance between bracketed samples was determined using a one-way ANOVA. Significance values are indicated by asterisks (P < 0.05 (*); P < 0.005 (**); P < 0.0005 (***); P <000.1 (****)).