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Sequence of SMG-2. The sequence of SMG-2, deduced from cDNA clone TR#192, is aligned with those of Upf1p and RENT1/HUPF1. Amino acid residues identical in two or three of these three proteins are shaded with light gray and dark gray, respectively. The highly homologous zinc finger and RNA helicase domains are boxed with dotted and solid lines, respectively. The carboxyl termini of SMG-2 and RENT1/HUPF1 are rich in SQ dipeptides, which are underlined.
