Table 1.
Original coronavirus reference strain and tryptic and GluC proteolytic segments that contain sites of mutations in surface spike protein within five major variants of concern
| Lineage | Strainorigin | Sites of mutations in major variants | Tryptic + GluC segmenta | Sequencea | Mass [M + H]+ mono. |
|---|---|---|---|---|---|
| Reference | Wuhan, China | L18 or T19 or T20 | 1–21 | MFVFLVLLPLVSSQCVNLTTR | 2380.3132 |
| P26 | 22–34 | TQLPPAYTNSFTR | 1495.7540 | ||
| HV del 69–70 | 54–77 | LFLPFFSNVTWFHAIHVSGTNGTK | 2720.3984 | ||
| D80 | 79–80 | FD | 281.1132 | ||
| T95 | 89–96 | GVYFASTE | 873.3990 | ||
| D138 | 133–138 | FQFCND | 773.2923 | ||
| G142 or Y del 144 | 139–147 | PFLGVYYHK | 1123.5935 | ||
| E154 | 151–154 | SWME | 552.2123 | ||
| R158 or del 156–157 | 155–158 | SEFR | 538.2620 | ||
| R190 | 188–190 | NLR | 402.2460 | ||
| D215 | 215 | D | 134.0448 | ||
| 242–244 del. or R246I | 238–246 | FQTLLALHR | 1098.6419 | ||
| K417N | 409–417 | QIAPGQTGK | 899.4946 | ||
| L452 | 429–453 | FTGCVIAWNSNNLD | 1553.7053 | ||
| T478 + E484 | 472–484 | IYQAGSTPCNGVE | 1338.5995 | ||
| N501 | 499–504 | STNLVK | 661.3880 | ||
| A570 | 569–571 | IAD | 318.1660 | ||
| D614 | 587–614 | ITPCSFGGVSVITPGTNTSNQVAVLYQD | 2868.4084 | ||
| H655 | 655–661 | HVNNSYE | 862.3690 | ||
| P681 | 664–682 | IPIGAGICASYQTQTNSPR | 1976.9859 | ||
| A701 | 686–702 | SVASQSIIAYTMSLGAE | 1727.8521 | ||
| T716 | 703–725 | NSVAYSNNSIAIPTNFTISVTTE | 2443.1988 | ||
| D950 | 948–950 | LQD | 375.1875 | ||
| S982 | 979–982 | ILSR | 488.3192 | ||
| T1027 | 1019–1028 | ASANLAATK | 846.4680 | ||
| D1118 | 1112–1118 | PQIITTD | 787.4197 | ||
| V1176 | 1169–1181 | ISGINASVVNIQK | 1342.7689 |
aBased on NCBI protein database sequence QHD43416.1