Fig. 5.

Sensitivity coefficient under parameter perturbation. We analyzed model sensitivity to perturbations in A,E) cell cycle time (${\tau }_{\text{P}}$), B,F) hypoxia threshold (θ_H), C,G) oxygen consumption (${\lambda }_c$), and D,H) FGF sensitivity threshold. Model responses to parameter perturbations were quantified base on the changes in A−D) tumor axial invasion rate and E−H) calcification growth rate. Model sensitivity was calculated using a sensitivity coefficient (SC), which quantifies change in model output per change in model input parameter (see Equation (6)).