TABLE I.

MODEL PARAMETERS

Model Parameter	Symbol	Baseline Value	Reference
Hypoxia threshold	${\theta }_{\text{H}}$	1/3 normoxia	[44, 47]
Oxygen diffusion constant	D oxygen	2.5 ×10−6cms−1	[48]
Blood oxygen concentration	$C_{O_2}$	100 mmHg	[44]
Estrogen diffusion constant	D estrogen	2.45 × 10−6 cm2 s−1	*
AREG diffusion constant	D AREG	3.18 × 10−7 cm2 s−1	[49]**
Proliferation rate (frequency)	${\lambda }_P$	≤ 1 per 16 hours	[50, 51]
Cell cycle time	${\tau }_{\text{P}}$	16 hours	[50, 51]
Progenitor symmetric proliferation probability	${\omega }_{\text{P}}$	100%
Proliferation cycles before differentiation	P max	50	[52, 53]
Stem cell symmetric proliferation probability	${\omega }_{\text{sc}}$	12%	[54]
Mature mammary cell radius	r	5μm	[51,55]
Healthy cell oxygen consumption rate	${\lambda }_{\text{H}}$	45 attoMol cell−1 sec−1	[55]
Cancer cell oxygen consumption rate	${\lambda }_{\text{C}}$	4.5x healthy cell rate	[55]
Hypoxia time to necrosis	${\tau }_{\text{N}}$	12 hours	[56]
Lysis volume increase due to swelling	$V_{\text{L}}$	100%	[57, 58]
Lysis time	${\tau }_{\text{L}}$	6 hours	[59]
Time to calcification	${\tau }_{\text{C}}$	14 days	[60]
Calcified volume % of pre-lysis cell volume	$V_{\text{C}}$	30%	[61]
Estrogen baseline† (% perturbation)		0.85 (0.05)
FGF baseline† (% perturbation)		0.5 (0.1)

Important model parameter baseline values. When not readily available in the literature, diffusion constants were estimated either through interpolation from values from structurally similar molecules (*) or from known values based on relative molecular weights (**). Other uncited values were determined from model calibration.

^†Normalized values. We have reduced the value for stem cell symmetric proliferation by 1% from [54].