Figure 1.

Kisspeptin and βhCG levels throughout the first trimester in healthy controls and women with miscarriages. (A) Scatterplot of plasma kisspeptin levels in healthy controls (gray) (n = 265 women providing 545 samples) and women with miscarriages (red) (n = 95 women providing 149 samples) over gestational age (weeks) calculated by LMP, during the first trimester. The data were analyzed by simple linear regression (r² = 0.31 for controls and 0.14 for women with miscarriages). ∗∗∗∗P<.0001 by analysis of covariance. (B) Median (IQR) plasma kisspeptin levels in healthy controls (gray) (n = 265 women providing 545 samples) and women with miscarriages (red) (n = 95 women providing 149 samples) over gestational age (weeks) calculated by LMP, during the first trimester. ∗∗P<.01, ∗∗∗∗P<.0001. (C) Scatterplot of plasma βhCG levels in healthy controls (gray) (n = 265 women providing 557 samples) and women with miscarriages (red) (n = 95 women providing 173 samples) over gestational age (in weeks) calculated by LMP, during the first trimester. (D) Median (IQR) plasma βhCG levels in healthy controls (gray) (n = 265 women providing 557 samples) and women with miscarriages (red) (n = 95 women providing 173 samples) over gestational age (weeks) calculated by LMP, during the first trimester. ∗P<.5, ∗∗P<.01, ∗∗∗∗P<.0001. βhCG = beta human chorionic gonadotropin; IQR = interquartile range; LMP = last menstrual period.