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. 2021 Sep;116(3):809–819. doi: 10.1016/j.fertnstert.2021.04.031

Figure 2.

Figure 2

MoM values for plasma kisspeptin and βhCG in healthy controls and women with miscarriages and their diagnostic performance. (A) Scatterplot of median (IQR) MoM of gestation-specific kisspeptin values in healthy controls (n = 265 women providing 545 samples) (gray) and women with miscarriages (n = 95 women providing 149 samples) (red). The groups were compared by the Mann-Whitney U test. ∗∗∗∗P<.0001. (B) Scatterplot of median (IQR) MoM of gestation-specific βhCG values in healthy controls (n = 265 women providing 557 samples) (gray) and women with miscarriages (n = 95 providing 173 samples) (red). The groups were compared by the Mann-Whitney U test. ∗∗∗∗P<.0001. (C) Scatterplot of median (IQR) MoM of gestation-specific kisspeptin and βhCG values in healthy controls (n = 265 women providing 538 samples) (gray) and women with miscarriages (n = 95 women providing 130 samples) (red). The groups were compared by the Mann-Whitney U test. ∗∗∗∗P<.0001. (D–F) ROC curves for MoM of kisspeptin (D), βhCG (E), and kisspeptin and βhCG (F). AuROC = area under the receiver-operating characteristic curve; βhCG = beta human chorionic gonadotropin; IQR = interquartile range; MoM = multiple of median. ROC = receiver-operating characteristic curve.