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. 2016 Apr 12;214(2):216–225. doi: 10.1093/infdis/jiw146

Figure 3.

Figure 3.

Higher cytomegalovirus (CMV) antibody titers but normal frequencies of functional CMV-reactive T cells in human immunodeficiency virus type 1 (HIV)–infected antiretroviral therapy (ART) recipients. A, Total anti-CMV immunoglobulin G (IgG) titers and high-avidity antibody titers were determined in CMV-positive HIV–infected ART recipients and uninfected controls. T-cell responses to CMV-specific peptides (pp65) were characterized by the analysis of cytokine production (interferon γ, tumor necrosis factor α, interleukin 2, and macrophage inflammatory protein 1β) and the degranulation marker CD107a in 22 HIV-infected ART recipients and 24 uninfected controls. Polyfunctionality of the CMV-specific cells was determined by the ability of the cells to produce different cytokines and the expression of the degranulation marker (CD107a). B and C, The proportion of cells that displayed ≥1 function of the total number of CMV-pp65 reactive CD4+ (B) and CD8+ (C) T cells is given. Open circles denote HIV-infected ART recipients, and closed circles denote uninfected controls.