Skip to main content
. Author manuscript; available in PMC: 2021 Sep 16.
Published in final edited form as: Cell Rep. 2021 Sep 7;36(10):109683. doi: 10.1016/j.celrep.2021.109683

Figure 3. The host responds to CDI-induced elevations in bile acid pools by reducing bile acid biosynthesis gene expression.

Figure 3.

(A) Schematic of key steps in the bile acid biosynthesis pathway in the murine liver. CYP7A1 controls bile acid pool size, CYP8B1 determines the ratio of cholate to chenodeoxycholate and muricholate, and BAAT conjugates bile acids with taurine or glycine.

(B–D) Expression of Cyp7a1 (B), Cyp8b1 (C), and Baat (D) in the livers of CDI mice relative to mock-infected mice over time. All expression values were first normalized to β-actin expression. Data plots show mean ± SEM; significance determined by unpaired two-sided t tests; n = 5 mice/group.