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. Author manuscript; available in PMC: 2021 Sep 16.
Published in final edited form as: Cell Rep. 2021 Sep 7;36(10):109683. doi: 10.1016/j.celrep.2021.109683

Figure 4. Elevated bile acid pool size is necessary for rapid host colonization and spore germination.

Figure 4.

CDI mice provided cholestyramine in their diet display delayed colonization relative to CDI mice provided a control diet without cholestyramine.

(A) Vegetative cell counts from fecal samples collected over time.

(B) CDI mice on a cholestyramine diet display delayed colonization compared with CDI mice on a control diet.

(C and D) Spore counts and vegetative cell counts (A) from fecal samples collected over time (C) were used to determine the ratio (D) of vegetative cells to spores in cholestyramine and control mice.

(E) CDI mice on a cholestyramine diet carry similar levels of primary bile acids in their ilea and ceca compared with CDI mice on a control diet at 3 DPI.

Data are represented as mean ± SEM; n.d., not detected; #, not detected in all mice; *p < 0.05, significance determined by unpaired two-sided t tests; n = 10 mice/group.