Table 2.
Antidepressant targets of active components from Puerariae Radix.
| Gene | Target name |
|---|---|
| NOS2 | Nitric oxide synthase 2 |
| CHRM1 | Cholinergic receptor muscarinic 1 |
| ESR1 | Estrogen receptor 1 |
| AR | Androgen receptor |
| PTGS2 | Prostaglandin-endoperoxide synthase 2 |
| PDE3A | Phosphodiesterase 3A |
| ADRA1D | Adrenoceptor alpha 1D |
| SLC6A3 | Solute carrier family 6 member 3 |
| ADRB2 | Adrenoceptor beta 2 |
| SLC6A4 | Solute carrier family 6 member 4 |
| ESR2 | Estrogen receptor 2 |
| DPP4 | Dipeptidyl peptidase 4 |
| MAPK14 | Mitogen-activated protein kinase 14 |
| GSK3B | Glycogen synthase kinase 3 beta |
| HSP90AA1 | Heat shock protein 90 alpha family class A member 1 |
| MAOB | Monoamine oxidase B |
| ACHE | Acetylcholinesterase (Cartwright blood group) |
| JUN | Jun protooncogene, AP-1 transcription factor subunit |
| IL4 | Interleukin 4 |
| SIRT1 | Sirtuin 1 |
| CHRM3 | Cholinergic receptor muscarinic 3 |
| KCNH2 | Potassium voltage-gated channel subfamily H member 2 |
| SCN5A | Sodium voltage-gated channel alpha subunit 5 |
| HTR3A | 5-Hydroxytryptamine receptor 3A |
| ADRA1B | Adrenoceptor alpha 1B |
| NCOA2 | Nuclear receptor coactivator 2 |
| DRD1 | Dopamine receptor D1 |
| CHRM4 | Cholinergic receptor muscarinic 4 |
| HTR2A | 5-Hydroxytryptamine receptor 2A |
| CHRM2 | Cholinergic receptor muscarinic 2 |
| CHRNA2 | Cholinergic receptor nicotinic alpha 2 subunit |
| OPRM1 | Opioid receptor Mu 1 |
| GABRA1 | Gamma-aminobutyric acid type A receptor subunit alpha1 |
| BCL2 | BCL2 apoptosis regulator |
| BAX | BCL2-associated X, apoptosis regulator |
| CASP9 | Caspase-9 |
| CASP3 | Caspase-3 |
| TGFB1 | Transforming growth factor beta 1 |
| PON1 | Paraoxonase 1 |
| MAP2 | Microtubule-associated protein 2 |
| GRIA2 | Glutamate ionotropic receptor AMPA type subunit 2 |
| NCOA1 | Nuclear receptor coactivator 1 |
| STAT3 | Signal transducer and activator of transcription 3 |
| AKT1 | AKT serine/threonine kinase 1 |
| VEGFA | Vascular endothelial growth factor A |
| FOS | Fos protooncogene, AP-1 transcription factor subunit |
| CD40LG | CD40 ligand |
| NFKBIA | NFKB inhibitor alpha |
| SOD1 | Superoxide dismutase 1 |
| HIF1A | Hypoxia-inducible factor 1 subunit alpha |
| FAS | Fas cell surface death receptor |
| VCAM1 | Vascular cell adhesion molecule 1 |
| PLAT | Plasminogen activator, tissue type |
| CYP19A1 | Cytochrome P450 family 19 subfamily A member 1 |
| GSTP1 | Glutathione S-transferase Pi 1 |
| SELP | Selectin P |
| AGTR1 | Angiotensin II receptor type 1 |
| AKR1B1 | Aldo-keto reductase family 1 member B |
| IFNB1 | Interferon beta 1 |
| GPT | Glutamic--pyruvic transaminase |
| PGP | Phosphoglycolate phosphatase |
| IFNA1 | Interferon alpha 1 |
| LEPR | Leptin receptor |
| F2R | Coagulation factor II thrombin receptor |