Table 3.
Core antidepressant targets of Puerariae Radix and their topological characteristics.
| Core gene | Target name | Degree | Betweenness centrality |
|---|---|---|---|
| AKT1 | AKT serine/threonine kinase 1 | 33 | 0.1808849 |
| FOS | Fos protooncogene, AP-1 transcription factor subunit | 28 | 0.12839175 |
| CASP3 | Caspase-3 | 27 | 0.05017522 |
| JUN | Jun protooncogene, AP-1 transcription factor subunit | 25 | 0.04969618 |
| VEGFA | Vascular endothelial growth factor A | 25 | 0.0346735 |
| STAT3 | Signal transducer and activator of transcription 3 | 24 | 0.02416106 |
| PTGS2 | Prostaglandin-endoperoxide synthase 2 | 22 | 0.01342578 |
| MAPK14 | Mitogen-activated protein kinase 14 | 20 | 0.00748504 |
| ESR1 | Estrogen receptor 1 | 19 | 0.00626354 |
| SIRT1 | Sirtuin 1 | 19 | 0.01170971 |
| HSP90AA1 | Heat shock protein 90 alpha family class A member | 18 | 0.04733413 |
| ACHE | Acetylcholinesterase (cartwright blood group) | 18 | 0.07253423 |
| SOD1 | Superoxide dismutase 1, soluble | 17 | 0.02514393 |
| HIF1A | Hypoxia-inducible factor 1 alpha subunit | 17 | 0.00556528 |
| AR | Androgen receptor | 16 | 0.0133448 |