Table 2.

Summary of IC₅₀ calculations for SARS-CoV-2 sulfated glycan inhibitors

Sulfated glycan	IC50 (mg/l)a	95% CI	pb	pc	pd
UFH	0.2497	0.09372–6.248	-	-	-
PpFucCS	0.0279	0.008141–0.09018	0.0149	-	-
IbFucCS	0.0217	0.006013–0.06791	0.0053	0.5840	-
IbSF	0.0196	0.005204–0.05298	0.0018	0.3999	0.9432

Abbreviation: 95% CI, 95% confidence limits.

^aIC₅₀ values of anti-SARS-CoV-2 inhibitory activity of heparin and holothurian sulfated glycans were determined against HEK 293T cells infected with baculovirus pseudotyped with SARS-CoV-2 (Wuhan strain) wildtype S-protein with 95% confidence limits.

^bp-Values were determined by comparing the IC₅₀ values of holothurian sulfated glycans with UFH using extra sum of squares F test.

^cp-Values were determined by comparing the IC₅₀ values of holothurian sulfated glycans with PpFucCS.

^dp-Values were determined by comparing the IC₅₀ values of holothurian sulfated glycans with IbFucCS.