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. 2021 Sep 17;37(1):109793. doi: 10.1016/j.celrep.2021.109793

Figure 2.

Figure 2

Characterization of inflammation signatures in COVID-19, sepsis, and HIV infection

(A) UMAP embeddings of cells colored by ten hyperinflammatory cell subtypes.

(B) The bar plots representing the inflammatory score of each hyperinflammatory cell subtype (top) and UMAP embeddings of cells colored by inflammatory score (bottom) in the COVID-19, sepsis, HIV infection, and HD groups. Error bars in the bar plots represent the 95% confidence intervals.

(C) UMAP embeddings showing the gene expression of TNF, IL6, and IL1B in the PBMCs from COVID-19, sepsis, HIV infection, and HD groups.

(D) Unsupervised hierarchical clustering of the Pearson correlation coefficients (PCCs) of the relative normalized gene expression of ten hyperinflammatory cell subtypes in the COVID-19, sepsis, and HIV infection. Color bars indicate the subtype and disease state (see legend for key).

(E) Heatmaps of the upregulated (left) and downregulated (right) biological pathways in COVID-19, sepsis, and HIV infection patients versus HDs.

(F) Heatmap of relative normalized gene expression of the enriched gene modules from weighted gene correlation network analysis (WGCNA). Color bars indicate the disease groups and subtypes (left, see legend for key). Top, a WGCNA dendrogram. Bottom, WGCNA gene modules. Mono, monocytes; Neu, neutrophils; Mega, megakaryocytes.