Table 1.
List of included inhalers and PIF cut-off levels
| Inhaler type | Assessment priority | Minimal PIF literature (L/min) | Optimal PIF literature (L/min) | Cut-off value for suboptimal PIF | In-Check DIAL setting |
|---|---|---|---|---|---|
| Ellipta [5, 40] | 1 | 30 | 60 | 60 | Medium/low |
| Turbuhaler [5, 40] | 2 | 30 | 60 | 60 | Different for different molecules |
| Breezhaler [5, 40] | 3 | 50 | 50 | 50 | Low |
| Zondaa | 4 | 20 | 39 | 30 | High |
| Genuair [5, 40] | 5 | 40 | 45 | 45 | Medium |
| Novolizer [5, 40] | 6 | 35 | 50 | 50 | Medium |
| Spiromax [5, 40] | 7 | 40 | 40 | 40 | Medium |
| Diskus [5, 40] | 8 | 30 | 60 | 60 | Medium/low |
| HandiHaler [5, 40] | 9 | 20 | 30 | 30 | High |
| NEXThaler [5, 40] | 10 | 35 | 35 | 35 | Medium/high |
| Cyclohaler (Aerolizer) [5] | 11 | 40 | 65 | 65 | Low |
| Easyhaler [5, 40] | 12 | 30 | 30 | N/A | N/A |
| Forspiro [41] | 13 | 30 | 60 | 60 | Medium |
| Elpenhalerb [42] | 14 | 30 | 60 | 60 | Different for different molecules |
| Clickhaler [37, 43] | 17 | 15 | 15 | N/A | Medium |
PIF, peak inspiratory flow
aPersonal communication. Teva Medical, 2020
bPersonal communication. Paul Hagedoorn, 2021