Table 5.

Parameter estimates of statistically significant miRNAs from full miRNA expression panel associated with employment duration and adjusted for structure fire-hours or structure fire-runs and time since most recent structure fire^a,b,c.

miRNA	Model with structure fire-hours							Model with structure fire-runs
	Employment duration		Structure fire-hours		Most recent structure fire		R2	Employment duration		Structure-fire-runs		Most recent structure fire		R2
	β	p value	β	p value	β	p value		β	p value	β	p value	β	p value
hsa-miR-494-3p	−0.735	<0.001	−0.392	0.025	−2.229	<0.001	0.778	−0.615	<0.001	−0.504	0.003	−2.247	<0.001	0.794
hsa-miR-422a	−0.439	<0.001	0.297	0.071	−1.321	<0.001	0.795	−0.370	<0.001	0.349	0.003	−1.346	<0.001	0.774
hsa-miR-26a-5p	−0.394	<0.001	0.272	0.120	0.403	<0.001	0.535	−0.403	<0.001	0.263	0.009	0.405	<0.001	0.756
hsa-miR-92a-3p	−0.366	<0.001	0.259	0.005	1.295	<0.001	0.618	−0.345	<0.001	−0.312	0.247	1.329	<0.001	0.611
hsa-let-7f-5p	–	–	–	–	–	–	–	−0.324	<0.001	0.243	0.007	0.388	0.008	0.443
hsa-miR-548a-3p	0.382	<0.001	0.259	0.103	0.398	0.017	0.480	–	–	–	–	–	–	–
hsa-miR-556-3p	0.396	<0.001	0.283	0.022	0.408	<0.001	0.407	0.424	<0.001	0.299	0.077	0.548	<0.001	0.408
hsa-miR-548ad-3p	0.469	<0.001	0.314	0.009	−1.960	0.008	0.426	0.471	<0.001	−0.403	0.002	−1.948	0.009	0.426
hsa-miR-525-3p	0.519	<0.001	−0.325	0.136	0.552	<0.001	0.568	0.529	<0.001	−0.338	0.118	−0.623	<0.001	0.570

Models also adjusted for age, BMI, ethnicity, batch effects, and Bonferroni correction. Associations significant after Bonferroni correction are in bolded text.

β Log₂FC, FC fold-change.

^aFor employment duration, effect is for a 6 month increase. For fire-hours, effect is for a 10 h increase. For fire-runs, effect is for a 10 fire increase.

^bBased on the highest Akaike information criteria (AIC), the best measure of time since most recent fire was selected (continuous, split at median value, split at tertile values, or split at quartile values). Hsa-miR-26a-5p, hsa-miR-548a-3p, hsa-miR-556-3p and hsa-let-7f-5p used time split at the median. Hsa-miR-494-3p, hsa-miR-422a, hsa-miR-92a-3p and hsa-miR-548ad-3p used time split at quantiles. Hsa-miR-525-3p used time split at the median for the model adjusted for structure fire-hours and time split at tertiles for the model adjusted for structure fire-runs.

^cAn absolute FC >1.25 was applied to statistically significant miRNAs associated with length of service presented here.