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. 2021 Aug 23;297(3):101111. doi: 10.1016/j.jbc.2021.101111

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Ghrelin improved endothelial cell migration and differentiation ability impaired by LPS.A, effect of ghrelin at a concentration of 100 nM on the migration of endothelial cells. Cells were divided into four groups, the control group, ghrelin group, LPS group, and ghrelin + LPS group. Yellow line delineates the margin of the recovery. Images were captured at 5× magnification. B, Matrigel tube formation assay was performed to assess the effect of ghrelin on angiogenesis. C and D, graphical representation summarizing data from four different experiments in endothelial cells. Ghrelin significantly improves the migration and tube formation of endothelial cells under LPS insult condition. N = 6, ∗p < 0.05 compared with the control group, ^#p < 0.05 compared with the LPS group. LPS, lipopolysaccharide.