Figure 10.

A T cell–mediated microenvironment was required in the development of CRC. (A) AOM/DSS-induced CRC model was generated (n = 10). The relative weight was measured. (B) Survival rate. (C) Number of polyps per mouse. (D) Polyp size (n = 6). (E) Hematoxylin and eosin staining (scale bar = 100 μm). Expression of IDO was detected by immunochemical staining of paraffin-embedded colon sections (scale bar = 100 μm). (F) Average Histology Score of colons (n = 6). The results are representative of at least 6 independent experiments and expressed as mean ± SD. ∗P < .05, ∗∗P < .01 indicates significant difference.