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. 2021 Jun 1;12(4):1179–1199. doi: 10.1016/j.jcmgh.2021.05.018

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

IDO/Kyn played a vital role in chronic colitis-associated cancer. (A) Induction procedure and groups designed for the AOM/DSS model of chronic colitis-associated cancer (n = 10). (B) Body weight. (C) Survival rate. (D) Number of polyps per mouse. (E) Polyp size (n = 6). (F) Hematoxylin and eosin staining (scale bar = 100 μm). (G) Average Histology Score of colons (n = 6). (H) Colon length (n = 6). The results are representative of at least 6 independent experiments and expressed as mean ± SD. ∗P < .05, ∗∗P < .01 indicates significant difference.