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. Author manuscript; available in PMC: 2022 Sep 8.
Published in final edited form as: Cell Host Microbe. 2021 Sep 1;29(9):1454–1468.e4. doi: 10.1016/j.chom.2021.08.003

Figure 2: Cage-specific subsets of barcoded strains quickly expand in abundance due to selection of mutations in motility- and metabolism-related genes.

Figure 2:

A-C) Relative abundances of barcodes (top) and mutations (bottom) in two representative mice within each cage of S1 mice. In all three cages, S1–36 took over; this strain harbors mutations in lacI and large motility deletions such as [flhE-flhD]. The other strains that bloomed were cage-specific.

D) Relative abundances of barcodes (top) and mutations (bottom) in two representative S2 mice. Multiple waves of partial barcode takeover occurred, with several barcodes persisting at >5% by day 19.

E) On day 4, relative abundances between mice in the same cage were much more variable compared to on day 19, despite differences among cages.