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. 2021 Sep 16;11:18430. doi: 10.1038/s41598-021-97855-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Heat map for the mean values of fold changes in concentrations of plasma metabolites at all the experimental time points and baseline (T1) in septic and sham animals separately. Lipids are summed up and ratios associated to the pathways of urea and ammonia detoxification, arginine and phenylamine. For the acronyms see Table S1; AA amino acids, Glucogenic AA sum of all glucogenic amino acids (Alanine Arginine, Asparagine, Aspartic acid, Cysteine, Glutamic acid, Glutamine, Glycine, Histidine, Methionine, Proline, Serine, Valine), Tot LPC/PC ratio of the total amount of lysoPC and PC species, Tot PC total amount of PC species, LPC16 + LPC18 total amount of the most abundant lysoPC (lyso PC 16:X and lyso PC 18:X), Tot SM total amount of sphingomyelin species, Fisher ratio ratio of branched-chain AAs (leucine, valine, isoleucine) to aromatic AAs (phenylalanine, tyrosine).