Table 1.
VIP scores of the PLS-DA model based on the fold-changes between T2 and T1 and between T5 and T1 plasma metabolite concentrations.
| Fold-change T2/T1 | Fold-change T5/T1 | ||
|---|---|---|---|
| Features | VIP | Features | VIP |
| Putrescine | 1.60 | ADMA | 1.519 |
| Gln | 1.43 | total DMA | 1.494 |
| Ala | 1.30 | Asp | 1.458 |
| lysoPC a C17:0 | 1.18 | Asn | 1.401 |
| PC aa C38:4 | 1.13 | Thr | 1.394 |
| PC aa C36:4 | 1.11 | alpha-AAA | 1.259 |
| PC aa C36:1 | 1.10 | Trp | 1.130 |
| PC aa C36:3 | 1.10 | Putrescine | 1.115 |
| PC aa C38:6 | 1.09 | C18:1 | 1.090 |
| PC ae C38:0 | 1.09 | Met | 1.051 |
| lysoPC a C18:1 | 1.07 | PC ae C40:1 | 1.045 |
| Cit | 1.07 | PC ae C38:0 | 1.032 |
| Kynurenine | 1.07 | PC aa C36:5 | 1.026 |
| lysoPC a C18:0 | 1.07 | PC aa C38:6 | 1.001 |
| lysoPC a C20:4 | 1.06 | Orn | 0.997 |
| Phe | 1.05 | Arg | 0.955 |
| PC aa C34:2 | 1.05 | PC aa C38:4 | 0.951 |
| PC ae C40:1 | 1.05 | C0 | 0.949 |
| PC aa C40:4 | 1.04 | lysoPC a C18:0 | 0.946 |
| lysoPC a C18:2 | 1.03 | t4-OH-Pro | 0.926 |
| PC ae C36:2 | 1.03 | lysoPC a C16:0 | 0.917 |
| lysoPC a C16:1 | 1.02 | Leu | 0.915 |
| PC ae C38:4 | 1.01 | lysoPC a C18:1 | 0.914 |
| PC ae C36:3 | 1.00 | Tyr | 0.910 |
| PC ae C42:2 | 0.97 | Val | 0.908 |
| PC ae C38:3 | 0.94 | PC ae C36:5 | 0.905 |
| PC aa C38:3 | 0.94 | PC ae C32:2 | 0.900 |
| PC ae C40:6 | 0.93 | SM C16:1 | 0.864 |
| PC aa C36:5 | 0.92 | lysoPC a C17:0 | 0.858 |
| PC ae C38:6 | 0.92 | PC ae C42:2 | 0.833 |
| PC aa C40:3 | 0.91 | Serotonin | 0.823 |
| PC aa C32:1 | 0.88 | PC ae C40:4 | 0.784 |
| PC ae C32:2 | 0.84 | PC ae C40:5 | 0.774 |
| PC aa C30:2 | 0.80 | PC ae C40:6 | 0.761 |
| PC aa C42:1 | 0.67 | His | 0.748 |
| PC ae C40:4 | 0.66 | PC aa C38:5 | 0.735 |
| PC aa C38:5 | 0.60 | PC aa C40:6 | 0.722 |
| PC aa C40:6 | 0.39 | PC aa C38:1 | 0.710 |
| Spermidine | 0.33 | SM C18:0 | 0.709 |
| SM C22:3 | 0.27 | PC ae C44:6 | 0.535 |
The models were built on the first 40 ranked features selected by a filter technique. A feature with a variable importance (VIP) score higher than 1 is considered significant in the classification model.