Fig. 1. Summary of clinical characteristics of the study cohort.

Clinical descriptions for each individual in the cohort are in Supplementary Table 1. a Availability of parental samples. b Sex. c Motor type and Topography (n = 150): Cases were classified according to topography categories: hemiplegia, diplegia or triplegia/quadriplegia. For motor type, cases with any report of dyskinetic/dystonic motor type are reported as dystonic. d Neonatal data: Gestational age was confirmed by case note review (n = 137). Personalised birth weight centiles for this cohort were calculated using the Gestation Related Optimal Weight (GROW) software⁶⁷ which accounts for individual physiological pregnancy variables (n = 118). e Comorbidities: Comorbidities were reported by parents and confirmed by clinical review where possible. Developmental delay reported in this cohort may include intellectual delays, as well as motor and other developmental delays. Data available: Autism n = 113, Developmental delay n = 130, Epilepsy n = 124, Visual impairment n = 116, Hearing impairment n = 110, Congenital abnormality n = 117.