Table 3.

Aetiological sub-types of genetic cerebral palsy identified in this study.

Aetiology	Causes	Associated genes
Stroke/cardiovascular	Thrombophilic pathway Small vessel disease Congenital heart defects Vascular abnormalities	F8, F2, PROC/PDGFRB, COL4A1, COL4A2, TTN, NKX2-6, ARHGAP31, KLHL3, NF1, CLCN1/CFTR, CLCN2/CACNA1C
Hereditary spastic paraplegias	Diverse genetic causes	SPAST, TUBB4A, KIDINS220, ALDH3A2
Neurodevelopmental disorders	Brain malformations Ion channel defects Metabolic defects CNVs with NDD risk	GNB1, TUBA1A, GRIN2B, CPA6, MT-TL1, MFN2, SYNE2, SETX, CACNA1A, 9q33.1 del, 15q11-q13 dup, Xp22.3 del, 22q11.2 dup, 1q21.1 del