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. 2021 Sep 16;12:5473. doi: 10.1038/s41467-021-25383-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Synthetic scheme for PAMDA synthesis. b Chemical crosslinking mechanism of tetra-PEG-SH and PAMDA. c In vitro release of vancomycin from PEG-PAM single layer coating and 3 PEG-PAMDA layers coating. d Representative X-ray image of spine surgery model (e) Postoperative in vivo S. aureus bioluminescence signals (mean maximum flux [photons/sec/cm2/sr] (logarithmic scale) of single-layer PEG-PAM only and PEG-PAM with vancomycin on stainless spine implant. (n = 3 for PEG-PAM group, n = 3 for PEG-PAM + Vanc group). f Representative in vivo S. aureus bioluminescence on a color scale overlaid on grayscale images of PEG-PAM with vancomycin and PEG-PAM only groups of POD 0, 3, and 21. g Postoperative in vivo S. aureus bioluminescence signals (mean maximum flux [photons/sec/cm2/sr] (logarithmic scale)) of 3 layers PEG-PAMDA only and 3 layers PEG-PAMDA with vancomycin on stainless spine implant (n = 6 for 3 layers PEG-PAMDA group, n = 6 for 3 layers PEG-PAMDA + Vanc group). h Representative in vivo S. aureus bioluminescence on a color scale overlaid on grayscale images of 3 layers PEG-PAMDA with vancomycin and 3 layers PEG-PAMDA only groups of POD 0, 3, and 21. Statistics in (c, e, g) are a two-way-repeated measure-ANOVA with multiple comparisons post-test. The significance between treatment groups was not significant for (c) and (e) and *p = 0.0116 for (g) Data is plotted showing the Standard Error of the Mean for time longitudinal plots.