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. 2021 Sep 16;12(10):852. doi: 10.1038/s41419-021-04143-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A, B GSEA results: pyroptosis-related genes are upregulated in the infarcted myocardia at 24 h (A) and 72 h (B) of AMI model. C qRT-PCR results show the continuously increased expression levels of the representative pyroptosis marker genes along the AMI development (n = 3, **P < 0.01, ***P < 0.001, Student’s t test). D Western blotting shows the continuously increased protein levels of PRO-CASP1 and ACT-CASP1 along the AMI development. E The continuously increased activity of the pyroptosis marker gene Caspase1 during the AMI development (n = 3, *P < 0.05, **P < 0.01, ***P < 0.001, Student’s t test). F Electronic microscopic results show the morphologic changes in the AMI samples compared to the sham samples. Arrows indicate pyroptotic bodies (Bar = 1 μm). G The network composed of the pyroptosis signaling pathway genes indicates the active interactions. n.s. not significant.