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. 2021 Sep 16;11:18451. doi: 10.1038/s41598-021-97908-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Effects of drugs on the expression of iNOS, MMP-9, claudin-5, occludin and ZO-1protein levels in the ischemic brain tissue of MCAO rats. (A-D) represents protein level analysis of expression of iNOS, MMP-9, claudin-5, occludin and ZO-1. The values are presented as mean ± SD. (n = 6), *compared with the model group, *P < 0.05 and **P < 0.01. (b) Immunoblotting electrophoresis map of the ROS/RNS-MMPs-TJs pathway. Related indicators in the ischemic brain tissue of rats. Sham operation group (A), model group (B), Nimodipine injection group (C), E. breviscapus injection group (D), Scutellarin group (E) and 3,5-dicaffeoylquinic acid group (F).