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. 2021 Sep 16;11:16490. doi: 10.1038/s41598-021-95922-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Bilateral frontal regions responded to K448. (a) Stereo-EEG electrodes aggregated across subjects. (b) Linear mixed models revealed nonsignificant reductions in all regions other than the bilateral frontal cortices (right frontal cortex (FC) % reduction = 59.55, p = 0.049; left FC % reduction = 63.25, p = 0.017). “n” represents the number of subjects with electrode coverage in the corresponding brain region and “s” represents the number of unique experiment sessions. Significance at *p < 0.05, **p < 0.01, ***p < 0.001.