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. 2021 Sep 16;11:18499. doi: 10.1038/s41598-021-97533-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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LINC00152 knockdown enhances migration and invasion of A172 GBM cells. (a) Migration of cells after LINC00152 knockdown through a cell-free gap of defined width was compared to cells transfected with a negative control siRNA over time (n = 4) and pictures were taken every 6 h. The images were analyzed using a Scratch Assay Analyzer (ImageJ https://imagej.nih.gov/ij/). (b) After 24 h the gap was completely overgrown by LINC00152 knockdown cells and up to 70% by control cells. (c,d) Invasion of LINC00152 knockdown cells into a gel matrix was compared to control siRNA-treated cells over time. Pictures were taken every 24 h (d) and after 96 h the spheroid diameter was measured and compared between LINC00152 knockdown and control cells in four independent biological replicates (c).