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. 2021 Sep 16;11:18472. doi: 10.1038/s41598-021-97952-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Change in body composition and handgrip strength according to age. LTI and HGS decreased significantly with age, and FTI showed a U shape (top, female; bottom, male). (b) Change in body composition and handgrip strength according to the estimated glomerular filtration rate (eGFR). The change according to the eGFR did not show a significant difference in the fat tissue; however, the LTI tended to decrease somewhat as the renal function decreased. Above all, the HGS showed a significant decrease in the higher stage of chronic kidney disease (top, female; bottom, male).