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. 2021 Sep 16;11:18422. doi: 10.1038/s41598-021-97607-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Screenshot of the image viewer for the observer study. (A) previous computed tomography (CT) image (upper left); (B) current CT image (upper right); (C) projection of temporal subtraction (TS) images (lower left); (D) TS image (lower right). When an observer clicks on a suspicious lesion, the dialog box appears to rate its likelihood (low to high) of being a bone metastasis. These representative images are obtained from a 55-year-old male patient with renal cell carcinoma who developed two osteolytic metastases in a thoracic vertebra (red circle) and the left iliac bone (blue circle). Both metastases are clearly visualized.