Table 2.
Hospitalized patients in the infectious diseases and ICU departments: a three-periods assessment comparison. Bef-F: December 7th to 21st 2020, Aft1-F: January 24th to February 7th, Aft2-F: February 8th to 22nd.
| Infectious diseases patients | Bef-F n = 51 | Aft1-F n = 72 | Aft2-F n = 54 | p |
|---|---|---|---|---|
| 1st symptoms—admission—days (SD) | 7.5 (4.5) | 6.9 (3.3) | 9.4 (5.6)** | 0.01 |
| Age—mean (SD) | 70.7 (13.6) | 66.9 (15.8) | 59.2 (14.0)*,** | < 0.001 |
| Sex ratio (male/female) | 1.83 | 1.57 | 1.35 | 0.745 |
| Diabetes—n (%) | 17 (33%) | 16 (22%) | 12 (22%) | 0.306 |
| Hypertension—n (%) | 20 (39%) | 30 (42%) | 15 (28%) | 0.252 |
| Obesity—n (%) | 10 (20%) | 18 (25%) | 9 (17%) | 0.503 |
| Immunosuppression—n (%) | 4 (8%) | 5 (7%) | 1 (2%) | 0.341 |
| No comorbidity—n (%) | 8 (16%) | 18 (25%) | 23 (42%)*,** | 0.007 |
| Charlson Index (CCI)—mean (SD) | 1.3 (1.6) | 0.9 (1.0) | 0.6 (0.8)*,** | 0.04 |
| Clinical and radiological data | ||||
| Respiratory rate/min—mean (SD) | 25.0 (6.1) | 26.9 (5.8) | 24.9 ± (5.9) | 0.051 |
| Room air SpO2%—mean (SD) | 90.5 (7.2) | 91.2 (5.6) | 92.1 (4.6) | 0.335 |
| CRP mg/L—mean (SD) | 94.3 (85.9) | 108.8 (77.7) | 94.4 (68.2) | 0.316 |
| CT-scan opacitiesa over 50% (n, %) | 8 (16%) | 10 (14%) | 9 (17%) | 0.951 |
| ICU admission | 12 (23%) | 19 (26%) | 19 (35%) | 0.374 |
| ICU patients | Bef-F n = 13 | Aft1-F n = 20 | Aft2-F n = 22 | p |
|---|---|---|---|---|
| Age (years)—mean (SD) | 68.4 (10.8) | 64.5 (10.7) | 60.6 (12.5) | 0.154 |
| Male—n (%) | 9 (69%) | 13 (65%) | 16 (72%) | 0.863 |
| Mechanical ventilation—n (%) | 7 (54%) | 5 (25%) | 10 (45%) | 0.203 |
| HFNC—n (%) | 5 (38%) | 14 (70%) | 9 (45%) | 0.140 |
| SAPSII—mean (SD) | 40.6 (18.1) | 35.5 (15.3) | 40.0 (19.9) | 0.566 |
| Worst P/F—mean (SD) | 92 (33) | 112 (62) | 87 (24) | 0.244 |
Comparison between groups by a non-parametric one-way ANOVA on ranks (Kruskal–Wallis test). Post hoc analysis (Fischer exact-test or Mann–Whitney U-test, if required): *p < 0.05 versus December **p < 0.05 versus January.
aTypical Covid-19 related imaging such as subpleural ground-glass opacities and subsequent consolidations, small vessel or intralobular septum thickening (33,631,941).