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. Author manuscript; available in PMC: 2022 Jan 21.
Published in final edited form as: Pediatr Res. 2021 Mar 17;91(1):21–26. doi: 10.1038/s41390-021-01393-x

Figure 1. Pulmonary granulomas in infant macaques with tuberculosis.

Figure 1.

(A & B) Granulomas, comprising of macrophage layers (red) and clusters of CD20+ B cells (blue), are organized well with a central area of caseous necrosis (MPO-expressing neutrophils); (C-F) Less organized coalescing granulomas, surrounded by a layer of macrophages (green) and IDO-expressing cells (red, E & F) with infiltration of CD3+ T cells (red, C & D). Clustered 20+ B cells (blue) distributed along the layer. MPO, myeloperoxidase; IDO, Indoleamine-pyrrole 2,3-dioxygenase.